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Genome-wide mapping of H3K27me3 in Daxx-depleted cells

GSE38184 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/04/29 Platform GPL11154
Summary
We discovered Daxx can negatively regulated H3K27me3 level via facilitating long non-coding RNA HOTAIR degradation. To further explore the biological consequence and search for affected genes, we used high throughput sequencing technology to demonstrate the enrichment of H3K27me3 on the human genome and target genes repression after depletion of Daxx. This study revealed a novel role of Daxx in regulating histone modifications via modulates long non-coding RNA stability.
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Direct links to NCBI, no account and no request form: the whole study as GSE38184_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA167336 and SRA study SRP013351. Searching any of these in the dataset finder brings you back here.

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