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Expression data from transplanted HCmel3 mouse melanomas relapsing to adoptive T-cell therapy in vivo

GSE40213 Mus musculus Expression profiling by array 21 samples Submitted 2012/10/10 Platform GPL6887
Summary
Adoptive cell therapies (ACT) with cytotoxic T-cell targeting melanocytic antigens can achieve remissions in metastatic melanoma patients, but tumours frequently relapse. To study the underlying mechanisms of resistance we have generated a genetically engineered mouse melanoma model that faithfully recapitulates tumour regression, remission and relapse as seen in patients. HCmel3 mouse melanoma cells were injected into syngneic C57/BL6 (H-2b) mice. We performed transcriptional profiling of control, relapsed and re-transplanted relapsed tumours to characterize the changes in gene expression patterns associated with the respective treament conditions. In addition, we analysed the transcription profile of ACT relapsed melanoma cultures in vitro and the transcriptional response to the inflammatory cytokine Tnf-alpha. The study aimed to identify molecular mechanisms contributing to ACT resistance to optimize therapeutic regimens in the clinic.
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Direct links to NCBI, no account and no request form: the whole study as GSE40213_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 21 samples.

Also filed as BioProject PRJNA173206. Searching any of these in the dataset finder brings you back here.

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