GEO series

Hypoxic changes in gene expression: effect of vhl and p53 genotype

GSE4186 Homo sapiens Expression profiling by array 30 samples Submitted 2006/03/07 Platform GPL3423

Summary

Microarrray experiments were performed in order to identify genes whose expression is altered under hypoxic conditions and to determine whether these changes are dependant on the p53 and HIF tanscription factors. In order to determine HIF dependance, isogenic RCC4 cell lines were used that were either wildtype of null for vhl, the gene responsible for degrading HIF under normoxic conditions. In order to determine p53 dependance, isogenic HCT116 and H1299 cell lines that were wildtype or null for p53 were used. Gene expression was measured after exposure of cells in monolayer culture to hypoxia (<0.01% O2) for various times. Keywords: hypoxia, time course, genetic modification, cell line comparison

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Direct links to NCBI, no account and no request form: the whole study as GSE4186_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 30 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA95151. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 16517406) ↗

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