GEO series

Gene expression data from iPSC-derived neural cells, comparison between APP wild and E693delta mutation

GSE43326 Homo sapiens Expression profiling by array 6 samples Submitted 2013/03/22 Platform GPL6244

Summary

Oligomeric forms of amyloid-beta peptide (Abeta) are presumed to play a pivotal role in the pathogenesis of Alzheimer’s disease (AD). However, it is still unclear how Abeta oligomers contribute to AD pathogenesis in patient neural cells. We generated induced pluripotent stem cells (iPSCs) from a familial AD patient and differentiated them into neural cells. Abeta oligomers were accumulated in neural cells of AD bearing amyloid precursor protein (APP)-E693delta mutation. To uncover Abeta oligomers in AD(APP-E693delta) neural cells, we analyzed gene expression profiles of control and the AD neural cells

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Direct links to NCBI, no account and no request form: the whole study as GSE43326_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA185778. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 23434393) ↗

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