GEO series

Global profiling of human hair follicle scalp dermal papilla cells using Affymetrix microarrays

GSE44765 Homo sapiens (human) Expression microarray 18 samples Submitted 2013/10/20 Platform GPL570

At a glance

Expression microarray · human · 18 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Homo sapiens (human)
Samples: 18 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

Dermal papilla cells isolated from the human hair follicle are capable of inducing hair growth in recipient epithelia. However, demonstrating disparity from rodent dermal papilla, human cells lose this inductive competance immediately upon growth in culture under normal growth conditions. We grew dermal papilla cells in hanging drop cultures that are morphologically akin to intact dermal papilla, and found that by enhancing the environment for aggregation, we could restore the inductive capacity of human dermal papilla cells in culture.

Read the full summary ↓

The underlying genes that regulate the inductive potential of dermal papilla cells is not well understood, and we sought to use global profiling to identify key genes and pathways related to inductive competance within dermal papilla cells. We used Affymetrix microarrays to profile human dermal papilla cells in both hair inducing, and non-hair inducing states.

This dataset

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Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE44765_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA191608. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 24145441) ↗

Samples in this study

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+ 18 more — browse all 18 samples with per-sample file links →

Datasets on a similar topic

GSE193269 Comparative spatial transcriptomic and single-cell analyses of human nail units and hair follicles demonstrate transcriptional similarities between the onychodermis and follicular dermal papilla 21 samples shares follicle, papilla, dermal, hair
GSE291220 Serotonin activates dermal papilla cells and promotes hair growth 8 samples shares papilla, dermal, hair
GSE315061 Effects of oxytocin receptor agonists on the hair growth ability of dermal papilla cells 6 samples shares papilla, dermal, hair
GSE233904 Effects of oxytocin on the hair growth ability of dermal papilla cells 4 samples shares papilla, dermal, hair
GSE256023 Effects of WAY267464 or LIT001 on the hair growth ability of dermal papilla cells 3 samples shares papilla, dermal, hair
GSE3419 Characterization and isolation of stem cell enriched human hair follicle bulge cells 16 samples shares follicle, hair
GSE272333 TOWARDS THE GENERATION OF A LASER CAPTURE MICRODISSECTION-BASED HUMAN ANAGEN HAIR FOLLICLE TRANSCRIPTOME ATLAS 110 samples shares follicle, hair
GSE273109 Hair follicle stem cell fate supports distinct clinical endotypes in Hidradenitis Suppurativa 7 samples shares follicle, hair

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