Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 31 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 31 samples: 9 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE44931_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA192545 and SRA study SRP017210. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 9 replicated groups read from 31 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM1038270 H2171_BRD4
- GSM1038271 MM1.S_BRD4_500nM_JQ1
- GSM1038272 MM1.S_BRD4_50nM_JQ1
- GSM1038273 MM1.S_BRD4_5nM_JQ1
- GSM1038274 MM1.S_BRD4_5uM_JQ1
- GSM1038275 MM1.S_BRD4_DMSO
- GSM1038276 MM1.S_MED1_DMSO
- GSM1038277 MM1.S_RNA_POL2_500nM_JQ1
- GSM1038278 MM1.S_RNA_POL2_DMSO
- GSM1038284 U87_BRD4
- GSM1085732 MM1S_CDK9_500nM_JQ1
- GSM1085733 MM1S_MED1_500nM_JQ1
- GSM1085735 MM1.S_CDK9_DMSO
- GSM1094084 WT - replicate 1 WT
- GSM1094085 WT - replicate 2 WT
- GSM1094086 500nm JQ1 30 minute treatment - replicate 1 500nm JQ1 30 minute tre…
- GSM1094087 500nm JQ1 30 minute treatment - replicate 2 500nm JQ1 30 minute tre…
- GSM1094088 500nm JQ1 1 hour treatment - replicate 1 500nm JQ1 1 hour treatm…
- GSM1094089 500nm JQ1 1 hour treatment - replicate 2 500nm JQ1 1 hour treatm…
- GSM1094090 500nm JQ1 3 hour treatment - replicate 1 500nm JQ1 3 hour treatm…
- GSM1094091 500nm JQ1 3 hour treatment - replicate 2 500nm JQ1 3 hour treatm…
- GSM1094092 500nm JQ1 6 hour treatment - replicate 1 500nm JQ1 6 hour treatm…
- GSM1094093 500nm JQ1 6 hour treatment - replicate 2 500nm JQ1 6 hour treatm…
- GSM1094094 5nm JQ1 6 hour treatment - replicate 1 5nm JQ1 6 hour treatment
- GSM1094095 5nm JQ1 6 hour treatment - replicate 2 5nm JQ1 6 hour treatment
- GSM1094096 50nm JQ1 6 hour treatment - replicate 1 50nm JQ1 6 hour treatme…
- GSM1094097 50nm JQ1 6 hour treatment - replicate 2 50nm JQ1 6 hour treatme…
- GSM1094098 5000nm JQ1 6 hour treatment - replicate 1 5000nm JQ1 6 hour treat…
- GSM1094099 5000nm JQ1 6 hour treatment - replicate 2 5000nm JQ1 6 hour treat…
- GSM1094100 DMSO 6 hour treatment - replicate 1 DMSO 6 hour treatment
- GSM1094101 DMSO 6 hour treatment - replicate 2 DMSO 6 hour treatment
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.