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The Obesity-associated Fto gene regulates activity of the dopaminergic midbrain circuitry [WT]

GSE47215 Mus musculus Other; Methylation profiling by high throughput sequencing 6 samples Submitted 2013/06/15 Platform GPL13112
Summary
Here we use MeRIP-Seq to analyze global adenosine methylation (m6A) in mRNAs in the midbrain and striatum of Fto-deficient mice. We find that Fto deficiency leads to increased methylation within a subset of mRNAs important for neuronal signaling, including many within the dopaminergic signaling pathway. Collectively, our results show that Fto regulates demethylation of specific mRNAs in vivo, and this activity relates to control of dopaminergic transmission.
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Also filed as BioProject PRJNA205151 and SRA study SRP023108. Searching any of these in the dataset finder brings you back here.

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