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Genome wide profiling of RNA Polymerase II upon knock-down or overexpression of RECQL5

GSE49008 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2014/06/09 Platform GPL10999
Summary
RECQL5 globally effects the distribution of RNA Polymerase II on genes in a dose dependent manner. Knock-down of RECQL5 reduces RNA Polymerase II density in the gene body, while increasing density on TSS and TTS. Overexpression shows exactly the opposite effect. We postulate that RECQL5 acts as a regulator of the elongation rate, more specifically, that the knock-down increases elongation rate while the overexpression decreases it.
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Also filed as BioProject PRJNA212573 and SRA study SRP027563. Searching any of these in the dataset finder brings you back here.

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