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Methylation data from medulloblastoma tumor samples

GSE49576 Homo sapiens Methylation profiling by array 83 samples Submitted 2014/09/02 Platform GPL13534
Summary
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large cohort of SHH-MBs across all age groups by sequencing, DNA methylation and expression profiling. Our data show that most adults but only half of the pediatric patients with SHH-MB will respond to SMO inhibition as predicted by molecular analysis of the primary tumor and tested in the SHH-xenografts, demonstrating that the next generation of SMO-inhibitor trials should be based on these predictive biomarkers. To further dissect the biological differences between the different age groups within SHH medulloblastomas, we looked at the DNA methylation profiles of SHH medulloblastoma samples.
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Direct links to NCBI, no account and no request form: the whole study as GSE49576_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 83 samples.

Also filed as BioProject PRJNA214321. Searching any of these in the dataset finder brings you back here.

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