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A comparative encyclopedia of DNA elements in the mouse genome

GSE49847 Mus musculus Expression profiling by high throughput sequencing; Genome variation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing 588 samples Submitted 2013/08/14 Platform GPL15225Platform GPL9185Platform GPL9156Platform GPL13112Platform GPL10010Platform GPL11002Platform GPL11620Platform GPL9250
Summary
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organi- zation. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.
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Direct links to NCBI, no account and no request form: the whole study as GSE49847_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 588 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA215099. Searching any of these in the dataset finder brings you back here.

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