GEO series

Transcriptional analysis of human tonsil Tfh cells

GSE50391 Homo sapiens (human) Expression microarray 24 samples Submitted 2013/11/12 Platform GPL10558

At a glance

Expression microarray · human · 24 samples

What it is: Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism: Homo sapiens (human)
Samples: 24 samples
Data you can get: A processed expression table (series matrix) and the array files, from NCBI.

Summary (written by the submitters)

Follicular helper CD4 T (Tfh) cells provide B cells with signals that are important for the generation of high-affinity Abs and immunological memory and, therefore, are critical for the protective immunity elicited by most human vaccines. In this study we sought to define the gene expression signature of bona fide GC Tfh and Tfh cells.

This dataset

Open GSE50391 in finder → Find more human microarray datasets →

Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE50391_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA217399. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 24035365) ↗

Samples in this study

The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.

+ 24 more — browse all 24 samples with per-sample file links →

Datasets on a similar topic

GSE70580 Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs) 648 samples shares tonsil
GSE103412 Mucositis in patients with tonsil squamous cell carcinoma: gene expression profile of oral mucosa before, during, and after radiation therapy 64 samples shares tonsil
GSE260943 Mutability and hypermutation antagonize immunoglobulin codon optimality; Analysis of human tonsil B cells. 6 samples shares tonsil
GSE262622 Distinct localization, transcriptional profiles, and functionality in early life tonsil regulatory T cells 38 samples shares tonsil
GSE240441 scRNAseq of human blood, tonsil, lung and small intestine innate lymphoid cells 18 samples shares tonsil
GSE178178 Transcriptomic analysis of Hsp90 inhibitor (Hsp90i)-treated HIV-infected pediatric tonsillar mononuclear cells 16 samples shares tonsil
GSE218131 Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype in tonsils and blood 33 samples shares tonsil
GSE166773 Next generation sequencing facilities quantitative analysis of human oropharyngeal squamous cell carcinoma, small cell carcinoma and non-cancerous tonsil tissue. 3 samples shares tonsil

Search all human microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.