GEO series

Similarities and differences between human activated macrophages II

GSE51446 Homo sapiens Expression profiling by array 7 samples Submitted 2014/01/03 Platform GPL10558

Summary

We compare, in human macrophages, stimuli considered to induce M1 or M2 type of activation, also termed classical and alternative activation. This dataset highlights key differences between the M1 and M2 stimuli pointing to the need of a revision of the paradigm. Macrophages were left untreated or stimulated with IL-4 and IL-13 (prototypic M1 stimuli), Dexamethasone (Glucocorticoid receptor agonist) which has been hitherto considered M2, IL-10 which also falls under the M2 umbrella, and LPS and Interferon Gamma considered M1 stimuli.

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Direct links to NCBI, no account and no request form: the whole study as GSE51446_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA232932. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 23293084) ↗

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