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Dexamethasone treatment of VCaP prostate cells

GSE51872 Homo sapiens Expression profiling by array 12 samples Submitted 2013/12/27 Platform GPL10558
Summary
The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. We identified glucocorticoid receptor (GR) activity as modulator of enzalutamite sensitivity in the VCaP prostate cancer cell line. The GR agonist dexamethasone was sufficient to confer enzalutamide resistance whereas a GR antagonist restored sensitivity. These expression profiling data demonstrate that GR transcriptional activity overlaps with that of AR in the VCAP model.
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Also filed as BioProject PRJNA225672. Searching any of these in the dataset finder brings you back here.

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