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CRL4(CRBN) ubiquitin ligase profiling

GSE57554 Homo sapiens Protein profiling by protein array 16 samples Submitted 2014/05/13 Platform GPL14689
Summary
In the 1950s the drug thalidomide administered as a sedative to pregnant women led ot the birth of thousands of children with multiple defects. Despite its teratogenicity, thalidomide and ist IMiD derivatives recently emerged as effective treatments for multiple myeloma and 5q-dysplasia. IMiDs target the CUL4-RBX1-DDB1-CRBN (CRL4(CRBN)) ubiquitin ligase. Through an unbiased screen we identify the homeobox trranscription factor MEIS2 as an endogenous substrate of CRL4(CRBN).
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Also filed as BioProject PRJNA246700. Searching any of these in the dataset finder brings you back here.

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