GEO series

mRNA expression data from adenoma, gene modified, and colorectal cancer organoid.

GSE57965 Homo sapiens Expression profiling by array 23 samples Submitted 2015/01/18 Platform GPL15207

Summary

We established human colorectal tumor organoids from benign adenoma, primary colorectal cancer or metastasized colorectal cancer. The gene signature of tumor organoids associated with their tumor progression status. We also generated genome-edited organoids from human intestinal organoids recapitulating adenoma-carcinoma sequence. Gene expression signature of the genome engineered organoids were similar to that of adenoma organoids. This result indicated multiple (up to five) genetic mutations were insufficient for gene expression reprogramming of colorectal cancer. We used microarrays to detail the global program of gene expression in human colorectal tumor organoids and artificially mutation introduced organoids.

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Direct links to NCBI, no account and no request form: the whole study as GSE57965_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 23 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA248589. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 25706875) ↗

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