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Regulation of gene expression by loss-of-YAP/TAZ in MDA-MB-231 breast cancer cells

GSE59230 Homo sapiens Expression profiling by array 12 samples Submitted 2015/03/23 Platform GPL570
Summary
YAP1 (Yes-associated protein 1) and TAZ (transcriptional coactivator with PDZ-binding motif, or WWTR1) are nucleo-cytoplasmic shuttling proteins that can function in the nucleus as transcriptional coactivators. Their role in regulating gene transcription has been so far mainly investigated by overexpressing YAP1 or TAZ, while here we sought to determine which genes are regulated by endogenous levels of YAP/TAZ. To this end, we compared MCF10A cells transfected with a control non-targeting siRNA to cells transfected with two independent mixes of siRNA targeting both YAP and TAZ.
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Also filed as BioProject PRJNA254774. Searching any of these in the dataset finder brings you back here.

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