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PPARγ controls alveolar macrophage identity [part1]

GSE60247 Mus musculus Expression profiling by array 8 samples Submitted 2014/09/28 Platform GPL11533
Summary
Tissue-resident macrophages comprise heterogeneous populations with unique functions and distinct gene expression signatures. While it has been established that they mostly originate from embryonic progenitors, the signals inducing a characteristic tissue-specific differentiation program remain unknown. Here we identify PPARγ as the crucial transcription factor determining perinatal alveolar macrophage (AM) development and identity. Development of the fetal monocyte derived AM precursor was largely abrogated in CD11c-Cre/Ppargfl/fl mice. To reveal the underlying changes in gene expression, we performed microarray analysis of sorted WT and KO AM and pre-AM from 3 different timepoints. Part1: d2 and d11 sorts & array
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Also filed as BioProject PRJNA257838. Searching any of these in the dataset finder brings you back here.

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