GEO series

Human mesenchymal stem cells

GSE6460 Homo sapiens Expression profiling by array 7 samples Submitted 2007/12/06 Platform GPL570

Summary

The identity of cells that establish the hematopoietic microenvironment (HME) in human bone marrow (BM), and of skeletal ("mesenchymal") stem cells (SSCs) found in BM stroma, have long remained elusive. We show that MCAM/CD146-expressing, subendothelial cells in human BM stroma are both the self-renewing SSCs and the cells that transfer the HME at heterotopic sites upon transplantation. Establishment and self-renewal of SSCs in developing BM in vivo occurs via specific, dynamic interactions with developing sinusoids. Non-differentiated SSCs residing on the sinusoidal wall, but not differentiated osteoblasts, express Angiopoietin-1 (a pivotal molecule of the HSC "niche" involved in vascular remodeling). Our data reveal the functional relationships between establishment of the HME in vivo, establishment of SSCs in BM sinusoids, and angiogenesis. Keywords: comparative genomics, genetic modification

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Direct links to NCBI, no account and no request form: the whole study as GSE6460_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples.

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Also filed as BioProject PRJNA98689. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 17956733) ↗

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