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Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

GSE65362 Homo sapiens Methylation profiling by genome tiling array 562 samples Submitted 2015/05/21 Platform GPL13534
Summary
Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
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Also filed as BioProject PRJNA273777. Searching any of these in the dataset finder brings you back here.

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