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A Circult Mechanism for Differentiating Positive and Negative Associations

GSE66345 Mus musculus Expression profiling by high throughput sequencing 17 samples Submitted 2015/02/27 Platform GPL17021Platform GPL19057
Summary
The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Different neuronal populations of the basolateral amygdala complex (BLA) encode fearful or rewarding associations, but the molecular identity of these functionally distinct populations of BLA neurons remained unknown. Here, we show that BLA neurons projecting to the nucleus accumbens (NAc-projectors) or the centromedial amygdala (CeM-projectors) underwent opposing synaptic changes following fear or reward conditioning. The photostimulation of NAc projectors supported positive reinforcement while photostimulation of CeM projectors mediated negative reinforcement. In search of defining molecular characteristics of these functionally-distinct BLA neuronal populations, we compared gene expression profiles of NAc- and CeM-projectors.
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Direct links to NCBI, no account and no request form: the whole study as GSE66345_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 17 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA276574 and SRA study SRP055558. Searching any of these in the dataset finder brings you back here.

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