GEO series

GDF11 is a myokine that inhibits muscle differentiation and induces atrophy during regeneration

GSE67326 Homo sapiens Expression profiling by array 56 samples Submitted 2015/05/20 Platform GPL570

Summary

Age-related frailty may in part be due to a decreased competency in skeletal muscle regeneration. The role of the closely related TGFbeta amily molecules myostatin and GDF11 in regeneration is unclear. The commercially available antibody which in a prior report was used to demonstrate an age-related decrease in GDF11 was found to detect both GDF11 and myostatin, and with this reagent it appears that the combination of GDF11 and myostatin increases with age in serum. Mechanistically, GDF11 and myostatin induce SMAD2/3 phosphorylation, and both inhibit myoblast differentiation and regulate identical downstream signaling. GDF11 injected into adult mice in a model of regeneration induces an increase in smaller fibers and a decrease in satellite cell expansion. There are no signs of benefit from GDF11 to regeneration. Thus, GDF11 appears to be an age-associated myokine that inhibits muscle differentiation, and is thus a target for blockade to treat frailty

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Direct links to NCBI, no account and no request form: the whole study as GSE67326_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 56 samples.

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Also filed as BioProject PRJNA279519. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 26001423) ↗

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