NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [N1ICD]
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE72404_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA293982 and SRA study SRP062871. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 24 more — browse all 24 samples with per-sample file links →
- GSE72409 NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence 48 samples shares notch1, reciprocal, secretomes, senescence, mediates, distinct, switch
- GSE72407 NOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence [CSM] 24 samples shares notch1, reciprocal, secretomes, senescence, mediates, distinct, switch
- GSE292924 Effects of Normoxia, Hypoxia, Oscillatory Hypoxia, and Lactate on Wild-Type, NOTCH1-Knockdown, and TP53-Knockdown MDA-MB-231 Cells 36 samples shares notch1
- GSE293100 Modulation of NOTCH1 signaling in CLL and MCL cell lines 30 samples shares notch1
- GSE288952 KROX20-Notch1 Network Transcriptionally Regulates Meibomian Gland Stem Cells for Its Development and Homeostasis 19 samples shares notch1
- GSE337220 Impaired mechanotransduction in second heart field-derived smooth muscle cells causes NOTCH1 haploinsufficiency-associated aortopathy 18 samples shares notch1
- GSE262001 Gene expression profiling of Triple Negative Breast Cancer MB157 cells and GSI-resistant MB157R cells upon induction of Notch1 or Sox2 signaling. 12 samples shares notch1
- GSE318807 Regulatory Elements Harboring Common Coronary Artery Disease Risk Variants Control Endothelial TSPAN14 Expression and NOTCH1 Signaling 12 samples shares notch1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.