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Expression data from human breast tissue

GSE7904 Homo sapiens Expression profiling by array 62 samples Submitted 2007/05/30 Platform GPL570
Summary
bulk breast tumor RNA from patient Abstract: Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic. total 62 sample incudes 43 tumor, 7 normal breast and 12 normal organelle Keywords: disease state analysis
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Direct links to NCBI, no account and no request form: the whole study as GSE7904_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 62 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA100077. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 16473279) ↗
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