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TCF1 is required for the generation of TCF1highTim3low virus-specific CD8 T cells

GSE85367 Mus musculus Expression profiling by array 18 samples Submitted 2016/12/22 Platform GPL16570
Summary
T-cell exhaustion is frequently observed during chronic viral infection and cancer. How exhausted T cells persist in the presence of immunosuppression is unclear. Here, we showed that virus-specific CD8 T cells differentiate into Tfh-like TCF1highTim3lowBlimp1low progenitors before the chronic phase of viral infection, which persist better than and can give rise to more terminal TCF1lowTim3highBlimp1high cells. Differentiation of TCF1high cells is driven by master regulator TCF1. Cell-intrinsic TCF1 deficiency led to sharp contraction and eventual deletion of virus-specific CD4 and CD8 T cells and uncontrolled viremia
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Also filed as BioProject PRJNA338284. Searching any of these in the dataset finder brings you back here.

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