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Histone modification and RNA changes in macrophages exposed to Beta-glucan and Fumarate

GSE86940 Homo sapiens Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2016/11/01 Platform GPL11154
Summary
Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components such as Beta glucan. We apply an epigenomic approach to characterize the molecular events involved in fumarate or BG induced trained innate immunity. ChIP-seq and RNA-seq data were generated. This analysis identified epigenetic programs in trained macrophages, with fumarate exposure inducing a small subset of BG-induced histone acetylation and methylation changes.
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Also filed as BioProject PRJNA343035 and SRA study SRP089893. Searching any of these in the dataset finder brings you back here.

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