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Global transcriptional profiling confirmed failed decidualization of human Endometrial Stromal Cells (hESCs) obtained from non-pregnant women with a previous pregnancy complicated by severe preeclampsia (sPE).

GSE91077 Homo sapiens Expression profiling by array 20 samples Submitted 2016/12/16 Platform GPL13497
Summary
The data presented here suggested that sPE is associated with impaired decidualization. Initial experiments involved an in vitro approach. hESCs were isolated from patients who developed sPE in a previous pregnancy or control women who had normal obstetric outcomes. Function was tested by comparing the ability of hESCs in the two groups to decidualize in culture. By morphological criteria and marker expression (PRL and IGFBP1), the cells in the formerly sPE group were decidualization resistant, which was confirmed by microarray analyses showing that they were transcriptionally inert.
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Also filed as BioProject PRJNA356828. Searching any of these in the dataset finder brings you back here.

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