← BioTransfer GEO Dataset Finder
GEO series

Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient

GSE92780 Homo sapiens Expression profiling by array 7 samples Submitted 2017/07/14 Platform GPL23126
Summary
We present an exceptional responder case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesion during a treatment-free period. Using an immunogenomics approach, we found that progressing metastases were infiltrated by CD8+ and CD4+ T cells, exhibited oligoclonal expansion of specific T-cell subsets, and showed indications of neoepitope depletion. These findings imply that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogenous fates of metastatic lesions often observed in the clinic post therapy. The goal of this particular experiment was quantify RNA expression using microarrays, and then evaluate differentially expressed genes and pathways between the different tumor samples.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE92780_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples.

Also filed as BioProject PRJNA358593. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 7 more — browse all 7 samples with per-sample file links →

Similar datasets

Search all human microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.