Distinct driver genes and the expression of Hedgehog defines morphoeic basal cell carcinoma
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Basal cell carcinomaThis series is part of our curated briefing on it.
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- GLI2 and FLNB Define Periocular Morphoeic Basal Cell CarcinomaInternational journal of molecular sciences · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE93797_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA362365 and SRA study SRP096981. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM2462232 nodBCC3 stromal RNAseq
- GSM2462233 nodBCC3 tumour RNAseq
- GSM2462234 nodBCC4 stromal RNAseq
- GSM2462235 nodBCC4 tumour RNAseq
- GSM2462236 nodBCC11 stromal RNAseq
- GSM2462237 nodBCC11 tumour RNAseq
- GSM2462238 mBCC1 stromal RNAseq
- GSM2462239 mBCC1 tumour RNAseq
- GSM2462240 mBCC2 stromal RNAseq
- GSM2462241 mBCC2 tumour RNAseq
- GSM2462242 mBCC3 stromal RNAseq
- GSM2462243 mBCC3 tumour RNAseq
- GSE269601 COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma 21 samples same disease briefing · shares basal
- GSE268728 A neoadjuvant, phase II trial demonstrates efficacy and tolerability of Talimogene laherparepvec in cutaneous basal cell carcinoma (NeoBCC trial) 12 samples same disease briefing · shares basal
- GSE266665 Investigating transcriptional programs regulating invasion in basal cell carcinoma 6 samples same disease briefing · shares basal
- GSE58377 SMO variants explain the majority of drug resistance in basal cell carcinoma 107 samples same disease briefing · shares basal
- GSE2959 Genome-wide SNP Microarray Mapping in Basal Cell Carcinomas Unveils Uniparental Disomy as a Key Somatic Event. 28 samples same disease briefing · shares basal
- GSE337786 Integrated multi-omics reveals the cellular and molecular interactions governing the invasive niche in skin cancer II 2 samples same disease briefing
- GSE330551 Th2-primed innate immune amplification defines a distinct atopic dermatitis endotype 174 samples shares distinct, defines
- GSE269942 YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilities 12 samples shares distinct, defines
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.