H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers
RNA-seq (gene expression) · human · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 21 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE95011_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA375127 and SRA study SRP098887. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 21 more — browse all 21 samples with per-sample file links →
- GSE94528 H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers [K562] 12 samples shares h3b-8800, spliceosome, modulator, lethality, splicing, induces, mutant, oral
- GSE94999 H3B-8800, a novel oral splicing modulator, induces lethality in spliceosome mutant cancers [Nalm-6] 9 samples shares h3b-8800, spliceosome, modulator, lethality, splicing, induces, mutant, oral
- GSE241672 Integrating Gene Expression and Splicing Dynamics Across Dose-Response Oxidative Modulators 400 samples shares modulator, splicing
- GSE303648 Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 co-inhibition in breast cancer 57 samples shares lethality, induces
- GSE304951 The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function 57 samples shares modulator, splicing
- GSE248036 XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells 42 samples shares lethality, induces
- GSE282741 Menin inhibitor DS-1594b drives differentiation and induces synergistic lethality in combination with Venetoclax in acute myeloid leukemia cells with rearranged MLL1 and NPM1 mutations 36 samples shares lethality, induces
- GSE312843 RBM39 Modulates UPR Signaling Through Alternative Splicing of IRE1α/ERN1 [Spliceosome_Inhibition_RNA-Seq] 20 samples shares spliceosome, splicing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.