GEO series

YTHDC2 regulates spermatogenesis through promoting the translation of N6-methyladenosine-modified RNA

GSE98085 Mus musculus (mouse) Other 16 samples Submitted 2017/08/01 Platform GPL20301Platform GPL21103

At a glance

mouse · 16 samples

Organism: Mus musculus (mouse)
Samples: 16 samples
Data you can get: A processed table (series matrix) and supplementary files from NCBI.

Summary (written by the submitters)

N6-methyladenosine (m6A) is the most common internal modification in eukaryotic mRNA. It is dynamically installed and removed, and acts as an essential layer of mRNA metabolism, regulating biological processes including stem cell pluripotency, cell differentiation, and energy homeostasis. m6A is recognized by selective binding proteins; YTHDF1 and YTHDF3 work in concert to promote the translation of m6A-containing mRNAs, YTHDF2 expedites mRNA decay, and YTHDC1 affects the splicing of its targets.

Read the full summary ↓

The biological function of YTHDC2, the final member of the YTH protein family, remains unknown. We report that YTHDC2 selectively binds m6A along its consensus motif GGACU. YTHDC2 promotes translation of its targets, and associates with cellular fractions involved in translation initiation. Ythdc2 knockout mice are infertile and have significantly smaller testes compared to those of littermates. In the testes, Ythdc2 is temporally expressed as meiosis begins, and germ cells of Ythdc2 knockout mice do not develop past the spermatogonium stage. Thus, YTHDC2 is an m6A binding protein that plays essential roles in spermatogenesis.

This dataset

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Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

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Supplementary files

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All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

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Whole study · RAW.tar ↓

Also filed as BioProject PRJNA383941 and SRA study SRP104994. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 28809393) ↗

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