Histone demethylation and c-MYC activation enhance translational capacity in response to amino acid restriction [RNA-seq]
DNA methylation · human · 14 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 12 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Coordinated histone methylation loss and MYC activation promote translational capacity under amino acid restrictionCancer & metabolism · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE100303_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA391298 and SRA study SRP110024. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 14 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM2677623 HeLa_AA_mRNAseq_biological-replicate1
- GSM2677624 HeLa_NOAA_mRNAseq_biological-replicate1
- GSM2677625 HeLa_AA_controlKD_mRNAseq
- GSM2677626 HeLa_AA_Setd8KD_mRNAseq
- GSM2677627 HeLa_AA_controlKD+MYC_mRNAseq
- GSM2677628 HeLa_AA_Setd8KD+MYC_mRNAseq
- GSM2677629 HeLa_AA_chromRNAseq
- GSM2677630 HeLa_NOAA_chromRNAseq
- GSM2677631 HeLa_AA_mRNAseq_biological-replicate2
- GSM2677632 HeLa_NOAA_mRNAseq_biological-replicate2
- GSM2677633 HBTEC_AA_mRNAseq
- GSM2677634 HBTEC_NOAA_mRNAseq
- GSM2677635 IMR90_AA_mRNAseq
- GSM2677636 IMR90_NOAA_mRNAseq
- GSE327289 Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary Tauopathies 76 samples shares activation, rna-seq
- GSE312780 Blood-flow restriction resistance training improves skeletal muscle mitochondrial oxidative capacity and cardiovascular risk factors in type 2 diabetes 34 samples shares restriction, capacity
- GSE304579 Alternative End-Joining Activation by miR-21-5p Confers Radiation Resistance in Oral Squamous Cell Carcinoma [RNA-seq of SUGH-OSCC patient tumors] 34 samples shares activation, rna-seq
- GSE243185 Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing [RNA-seq] 18 samples shares activation, rna-seq
- GSE303856 CPSF73 activation and 3’ Pol II pausing are lost during read-through transcription after heat shock [RNA-seq] 14 samples shares activation, rna-seq
- GSE310281 Translational control by RPL22L1-specific ribosomes enhances DNA repair and chemoresistance 12 samples shares translational, enhance
- GSE305296 Activation of the aryl hydrocarbon receptor in human melanoma cells enhances cancer cell-intrinsic MHC-II expression 43 samples shares activation, enhance
- GSE279781 CD137 agonism enhances anti-PD1 induced activation of clonally expanded CD8+ T cells in a neoadjuvant pancreatic cancer clinical trial 30 samples shares activation, enhance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.