Activation of the aryl hydrocarbon receptor in human melanoma cells enhances cancer cell-intrinsic MHC-II expression
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 43 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- MelanomaThis series is part of our curated briefing on it.
- Samples
- 43 samples: 15 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanomaJournal of experimental & clinical cancer research : CR · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305296_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1305006. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 43 samples.
How we read this: 15 replicated groups read from 43 sample titles; they account for 43 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9144350 A375 Control ATAC Rep 1 A375 Control ATAC
- GSM9144351 A375 Control ATAC Rep 2 A375 Control ATAC
- GSM9144352 A375 Control ATAC Rep 3 A375 Control ATAC
- GSM9144353 A375 AHRKO ATAC Rep 1 A375 AHRKO ATAC
- GSM9144354 A375 AHRKO ATAC Rep 2 A375 AHRKO ATAC
- GSM9144355 A375 AHRKO ATAC Rep 3 A375 AHRKO ATAC
- GSM9144356 A375 ARNTKO ATAC Rep 1 A375 ARNTKO ATAC
- GSM9144357 A375 ARNTKO ATAC Rep 2 A375 ARNTKO ATAC
- GSM9144358 A375 ARNTKO ATAC Rep 3 A375 ARNTKO ATAC
- GSM9144359 SKMEL2 Control ChIP Rep 1 SKMEL2 Control ChIP
- GSM9144360 SKMEL2 Control ChIP Rep 2 SKMEL2 Control ChIP
- GSM9144361 SKMEL2 Control ChIP Rep 3 SKMEL2 Control ChIP
- GSM9144362 SKMEL2 AHROE ChIP Rep 1 SKMEL2 AHROE ChIP
- GSM9144363 SKMEL2 AHROE ChIP Rep 2 SKMEL2 AHROE ChIP
- GSM9144364 SKMEL2 AHROE ChIP Rep 3 SKMEL2 AHROE ChIP
- GSM9144365 SKMEL2 ARNTOE ChIP Rep 1 SKMEL2 ARNTOE ChIP
- GSM9144366 SKMEL2 ARNTOE ChIP Rep 2 SKMEL2 ARNTOE ChIP
- GSM9144367 SKMEL2 ARNTOE ChIP Rep 3 SKMEL2 ARNTOE ChIP
- GSM9144368 A375 Control RNA Rep 1 A375 Control RNA
- GSM9144369 A375 Control RNA Rep 2 A375 Control RNA
- GSM9144370 A375 Control RNA Rep 3 A375 Control RNA
- GSM9144371 A375 AHRKO RNA Rep 1 A375 AHRKO RNA
- GSM9144372 A375 AHRKO RNA Rep 2 A375 AHRKO RNA
- GSM9144373 A375 AHRKO RNA Rep 3 A375 AHRKO RNA
- GSM9144374 A375 ARNTKO RNA Rep 1 A375 ARNTKO RNA
- GSM9144375 A375 ARNTKO RNA Rep 2 A375 ARNTKO RNA
- GSM9144376 A375 ARNTKO RNA Rep 3 A375 ARNTKO RNA
- GSM9144377 WM115 DMSO RNA Rep 1 WM115 DMSO RNA
- GSM9144378 WM115 DMSO RNA Rep 2 WM115 DMSO RNA
- GSM9144379 WM115 DMSO RNA Rep 3 WM115 DMSO RNA
- GSM9144380 WM115 FICZ RNA Rep 1 WM115 FICZ RNA
- GSM9144381 WM115 FICZ RNA Rep 2 WM115 FICZ RNA
- GSM9144382 WM115 FICZ RNA Rep 3 WM115 FICZ RNA
- GSM9144383 A375 MHC-II+ screen Rep 1 A375 MHC-II+ screen
- GSM9144384 A375 MHC-II+ screen Rep 2 A375 MHC-II+ screen
- GSM9144385 A375 MHC-II+ screen Rep 3 A375 MHC-II+ screen
- GSM9144386 A375 MHC-II- screen Rep 1 A375 MHC-II- screen
- GSM9144387 A375 MHC-II- screen Rep 2 A375 MHC-II- screen
- GSM9144388 A375 MHC-II- screen Rep 3 A375 MHC-II- screen
- GSM9144389 WM115+IFN MHC-II+ screen Rep 1 WM115+IFN MHC-II+ screen
+ 3 more — browse all 43 samples with per-sample file links →
- GSE12391 Melanoma: comparison between common nevi, radial/vertical growth phase melanoma, metastases and dysplastic nevi 114 samples same disease briefing · shares melanoma
- GSE134459 Genome-wide maps of transcriptomic and epigenomic state in melanoma cell lines 73 samples same disease briefing · shares melanoma
- GSE230489 RNA-sequencing of cutaneous melanoma and non-small cell lung cancer biopsies 38 samples same disease briefing · shares melanoma
- GSE100797 Mutational and neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma 25 samples same disease briefing · shares melanoma
- GSE123728 Clinical and Immunologic Activity of a Single Dose of Neoadjuvant PD-1 Blockade and Predictors of Clinical Outcomes in Resectable Melanoma 24 samples same disease briefing · shares melanoma
- GSE130956 Investigation of ST8SIA1 expression in icaritin-treated and untreated melanoma cell lines 12 samples same disease briefing · shares melanoma
- GSE140150 A rare subpopulation of melanoma cells with low expression of metastasis suppressor NME1 has a neural crest-like phenotype and is highly metastatic in vivo 6 samples same disease briefing · shares melanoma
- GSE142751 Genome-wide maps of chromatin state in 142 cancer cell lines [cell line] 855 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.