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Expression difference between stem cell Krt6a+ and differentiated cell WAP+ in mammary precancerous early lesions

GSE107608 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2025/03/04 Platform GPL17021
Summary
The stem cell hierarchy of normal tissues has been studied extensively for cancer origin, but the stem cell hierarchy of precancerous lesions and its contribution to tumorigenesis remain elusive. Here, we report that in MMTV-Wnt1 transgenic mice, mammary precancerous lesions harbor both keratin 6a+ precancerous stem cells (pcSC) and more differentiated whey acidic protein (WAP)+ cells. The goal of these data was to understand expression differences between different subsets of cells in mammary precancerous early lesions. There are two cell lines Krt6a+ cells (stem cells) and WAP+ cell (more differentiated cells) from hyperplastic mammary glands in MMTV-Wnt1 mice.
Published in
Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes
Bu W, Liu Z, Jiang W et al. · Cancer research 2019 · PMID 30401712 · doi:10.1158/0008-5472.CAN-18-1087
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Also filed as BioProject PRJNA420757 and SRA study SRP125972. Searching any of these in the dataset finder brings you back here.

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