GEO series

Transcriptome analysis in the prefrontal cortex of different ASD mouse models treated with drug

GSE293709 Mus musculus (mouse) RNA-seq (gene expression) 1565 samples Submitted 2026/07/28 Platform GPL24247

At a glance

RNA-seq (gene expression) · mouse · 1565 samples

What it is: RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism: Mus musculus (mouse)
Samples: 1565 samples: 80 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.

SuperSeries — this record groups several sub-series.

Summary (written by the submitters)

This SuperSeries is composed of the SubSeries listed below.

This dataset

Open GSE293709 in finder → Find more mouse RNA-seq datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE293709_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1246058 and SRA study SRP575996. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Study design

80 conditions, mostly with about 5 replicates each

Adnp, HT, Vehicle, female, ×8 Adnp, HT, Vehicle, male, ×8 Adnp, WT, Vehicle, female, ×8 Adnp, WT, Vehicle, male, ×7 Adnp, HT, Fluoxetine, female, ×5 Adnp, HT, Fluoxetine, male, ×5 Adnp, HT, Lithium, male, ×5 Adnp, WT, Fluoxetine, female, ×5 +73 more

Supports a between-group comparison across 399 samples.

How we read this: 80 replicated groups read from the first 400 of 1565 sample titles; they account for 399 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM8886449 Adnp, HT, Fluoxetine, female, replicate1 Adnp, HT, Fluoxetine, f…
GSM8886450 Adnp, HT, Fluoxetine, female, replicate2 Adnp, HT, Fluoxetine, f…
GSM8886451 Adnp, HT, Fluoxetine, female, replicate3 Adnp, HT, Fluoxetine, f…
GSM8886452 Adnp, HT, Fluoxetine, female, replicate4 Adnp, HT, Fluoxetine, f…
GSM8886453 Adnp, HT, Fluoxetine, female, replicate5 Adnp, HT, Fluoxetine, f…
GSM8886454 Adnp, HT, Fluoxetine, male, replicate1 Adnp, HT, Fluoxetine, m…
GSM8886455 Adnp, HT, Fluoxetine, male, replicate2 Adnp, HT, Fluoxetine, m…
GSM8886456 Adnp, HT, Fluoxetine, male, replicate3 Adnp, HT, Fluoxetine, m…
GSM8886457 Adnp, HT, Fluoxetine, male, replicate4 Adnp, HT, Fluoxetine, m…
GSM8886458 Adnp, HT, Fluoxetine, male, replicate5 Adnp, HT, Fluoxetine, m…
GSM8886459 Adnp, HT, Lithium, female, replicate1 Adnp, HT, Lithium, fema…
GSM8886460 Adnp, HT, Lithium, female, replicate2 Adnp, HT, Lithium, fema…
GSM8886461 Adnp, HT, Lithium, female, replicate3 Adnp, HT, Lithium, fema…
GSM8886462 Adnp, HT, Lithium, female, replicate4 Adnp, HT, Lithium, fema…
GSM8886463 Adnp, HT, Lithium, male, replicate1 Adnp, HT, Lithium, male,
GSM8886464 Adnp, HT, Lithium, male, replicate2 Adnp, HT, Lithium, male,
GSM8886465 Adnp, HT, Lithium, male, replicate3 Adnp, HT, Lithium, male,
GSM8886466 Adnp, HT, Lithium, male, replicate4 Adnp, HT, Lithium, male,
GSM8886467 Adnp, HT, Lithium, male, replicate5 Adnp, HT, Lithium, male,
GSM8886468 Adnp, HT, Vehicle, female, replicate1 Adnp, HT, Vehicle, fema…
GSM8886469 Adnp, HT, Vehicle, female, replicate2 Adnp, HT, Vehicle, fema…
GSM8886470 Adnp, HT, Vehicle, female, replicate3 Adnp, HT, Vehicle, fema…
GSM8886471 Adnp, HT, Vehicle, female, replicate4 Adnp, HT, Vehicle, fema…
GSM8886472 Adnp, HT, Vehicle, female, replicate5 Adnp, HT, Vehicle, fema…
GSM8886473 Adnp, HT, Vehicle, female, replicate6 Adnp, HT, Vehicle, fema…
GSM8886474 Adnp, HT, Vehicle, female, replicate7 Adnp, HT, Vehicle, fema…
GSM8886475 Adnp, HT, Vehicle, female, replicate8 Adnp, HT, Vehicle, fema…
GSM8886476 Adnp, HT, Vehicle, male, replicate1 Adnp, HT, Vehicle, male,
GSM8886477 Adnp, HT, Vehicle, male, replicate2 Adnp, HT, Vehicle, male,
GSM8886478 Adnp, HT, Vehicle, male, replicate3 Adnp, HT, Vehicle, male,
GSM8886479 Adnp, HT, Vehicle, male, replicate4 Adnp, HT, Vehicle, male,
GSM8886480 Adnp, HT, Vehicle, male, replicate5 Adnp, HT, Vehicle, male,
GSM8886481 Adnp, HT, Vehicle, male, replicate6 Adnp, HT, Vehicle, male,
GSM8886482 Adnp, HT, Vehicle, male, replicate7 Adnp, HT, Vehicle, male,
GSM8886483 Adnp, HT, Vehicle, male, replicate8 Adnp, HT, Vehicle, male,
GSM8886484 Adnp, WT, Fluoxetine, female, replicate1 Adnp, WT, Fluoxetine, f…
GSM8886485 Adnp, WT, Fluoxetine, female, replicate2 Adnp, WT, Fluoxetine, f…
GSM8886486 Adnp, WT, Fluoxetine, female, replicate3 Adnp, WT, Fluoxetine, f…
GSM8886487 Adnp, WT, Fluoxetine, female, replicate4 Adnp, WT, Fluoxetine, f…
GSM8886488 Adnp, WT, Fluoxetine, female, replicate5 Adnp, WT, Fluoxetine, f…

+ 1525 more — browse all 1565 samples with per-sample file links →

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