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c-Maf-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

GSE108184 Mus musculus Expression profiling by high throughput sequencing 12 samples Submitted 2017/12/19 Platform GPL19057
Summary
Both microbial and host genetic factors contribute to the pathogenesis of autoimmune disease. Accumulating evidence suggests that microbial species that potentiate chronic inflammation, as in inflammatory bowel disease (IBD), often also colonize healthy individuals. These microbes, including the Helicobacter species, have the propensity to induce pathogenic T cells and are collectively referred to as pathobionts. However, an understanding of how such T cells are constrained in healthy individuals is lacking. For this study we wanted to compare the transcriptomes of H. hepaticus-specific T effector cells from mice that were IL-10-deficient to those that were Maf-deficient in the Treg compartment to determine if they share an inflammatory signature. We also compared Maf -sufficient and -deficient polyclonal iTreg to determine molecular targets of the TF c-Maf.
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Direct links to NCBI, no account and no request form: the whole study as GSE108184_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA422768 and SRA study SRP126932. Searching any of these in the dataset finder brings you back here.

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