IL-7 mediated immunoregulatory feedback loop promotes dampening of immune effector functions by hypoinflammatory monocytes.
RNA-seq (gene expression) · mouse · 305 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 305 samples: 305 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE228457_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA949947 and SRA study SRP429934. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 305 sample titles: 305 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7120828 High-proliferating Leishmania major infected-single cell#1 , Mouse#2_Left ear [1_A4]
- GSM7120829 High-proliferating Leishmania major infected-single cell#2 , Mouse#2_Right ear [1_A9]
- GSM7120830 High-proliferating Leishmania major infected-single cell#3 , Mouse#3_Right ear [1_B10]
- GSM7120831 High-proliferating Leishmania major infected-single cell#4 , Mouse#2_Left ear [1_B4]
- GSM7120832 High-proliferating Leishmania major infected-single cell#5 , Mouse#4_Right ear [1_B6]
- GSM7120833 High-proliferating Leishmania major infected-single cell#6 , Mouse#5_Left ear [1_B7]
- GSM7120834 High-proliferating Leishmania major infected-single cell#7 , Mouse#2_Right ear [1_B9]
- GSM7120835 High-proliferating Leishmania major infected-single cell#8 , Mouse#4_Left ear [1_C11]
- GSM7120836 High-proliferating Leishmania major infected-single cell#9 , Mouse#2_Right ear [1_C4]
- GSM7120837 High-proliferating Leishmania major infected-single cell#10 , Mouse#1_Left ear [1_D7]
- GSM7120838 High-proliferating Leishmania major infected-single cell#11 , Mouse#4_Left ear [1_E11]
- GSM7120839 High-proliferating Leishmania major infected-single cell#12 , Mouse#1_Left ear [1_E7]
- GSM7120840 High-proliferating Leishmania major infected-single cell#13 , Mouse#1_Right ear [1_F12]
- GSM7120841 High-proliferating Leishmania major infected-single cell#14 , Mouse#3_Right ear [1_F4]
- GSM7120842 High-proliferating Leishmania major infected-single cell#15 , Mouse#4_Left ear [1_F5]
- GSM7120843 High-proliferating Leishmania major infected-single cell#16 , Mouse#1_Left ear [1_F7]
- GSM7120844 High-proliferating Leishmania major infected-single cell#17 , Mouse#4_Right ear [1_G11]
- GSM7120845 High-proliferating Leishmania major infected-single cell#18 , Mouse#1_Right ear [1_G12]
- GSM7120846 High-proliferating Leishmania major infected-single cell#19 , Mouse#3_Right ear [1_G4]
- GSM7120847 High-proliferating Leishmania major infected-single cell#20 , Mouse#1_Right ear [1_G7]
- GSM7120848 High-proliferating Leishmania major infected-single cell#21 , Mouse#2_Left ear [1_G8]
- GSM7120849 High-proliferating Leishmania major infected-single cell#22 , Mouse#4_Right ear [1_H11]
- GSM7120850 High-proliferating Leishmania major infected-single cell#23 , Mouse#1_Right ear [1_H12]
- GSM7120851 High-proliferating Leishmania major infected-single cell#24 , Mouse#2_Left ear [1_H3]
- GSM7120852 High-proliferating Leishmania major infected-single cell#25 , Mouse#1_Right ear [1_H7]
- GSM7120853 High-proliferating Leishmania major infected-single cell#26 , Mouse#2_Left ear [2_A4]
- GSM7120854 High-proliferating Leishmania major infected-single cell#27 , Mouse#5_Left ear [2_A6]
- GSM7120855 High-proliferating Leishmania major infected-single cell#28 , Mouse#1_Right ear [2_A7]
- GSM7120856 High-proliferating Leishmania major infected-single cell#29 , Mouse#1_Right ear [2_A8]
- GSM7120857 High-proliferating Leishmania major infected-single cell#30 , Mouse#2_Right ear [2_A9]
- GSM7120858 High-proliferating Leishmania major infected-single cell#31 , Mouse#3_Left ear [2_B10]
- GSM7120859 High-proliferating Leishmania major infected-single cell#32 , Mouse#4_Left ear [2_B2]
- GSM7120860 High-proliferating Leishmania major infected-single cell#33 , Mouse#2_Right ear [2_B9]
- GSM7120861 High-proliferating Leishmania major infected-single cell#34 , Mouse#1_Left ear [2_C1]
- GSM7120862 High-proliferating Leishmania major infected-single cell#35 , Mouse#4_Right ear [2_C2]
- GSM7120863 High-proliferating Leishmania major infected-single cell#36 , Mouse#4_Right ear [2_D11]
- GSM7120864 High-proliferating Leishmania major infected-single cell#37 , Mouse#4_Right ear [2_E11]
- GSM7120865 High-proliferating Leishmania major infected-single cell#38 , Mouse#4_Left ear [2_E5]
- GSM7120866 High-proliferating Leishmania major infected-single cell#39 , Mouse#1_Right ear [2_E6]
- GSM7120867 High-proliferating Leishmania major infected-single cell#40 , Mouse#1_Left ear [2_E7]
+ 265 more — browse all 305 samples with per-sample file links →
- GSE228456 Cell-intrinsic effect of IL-7R signaling of monocytes within C57BL/6J mouse ears infected with Leishmania major [bulk RNA-seq] 87 samples shares il-7, monocytes
- GSE100048 m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway 36 samples shares il-7
- GSE256267 Neutralizing the IL-7Ra limits injury in ANCA-associated glomerulonephritis 11 samples shares il-7
- GSE315249 SOX11 Downregulation and IL-7/IL22RA2 Upregulation Might be a Potential Mechanism of Exosome in Promoting Schwann Cell Proliferation 9 samples shares il-7
- GSE237266 IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T-cell engager immunotherapy in solid tumors 8 samples shares il-7
- GSE201486 The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression II 8 samples shares il-7
- GSE249674 Intratumoral administration of lipid nanoparticles carrying mRNA encoding for IL-21, IL-7, and 4-1BBL induces anti-tumor immunity in preclinical tumor models. 6 samples shares il-7
- GSE293085 Lymphocyte apoptosis and impaired type-17 immunity underlie mucosal candidiasis in DOCK8 deficiency and can be rescued by IL-7 immunotherapy 6 samples shares il-7
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.