GEO series

Genome-wide analysis of estrogen receptor binding sites

GSE11324 Homo sapiens Expression profiling by array 12 samples Submitted 2008/05/02 Platform GPL570

Summary

The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation,particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. Keywords: estrogen effect, time course

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Direct links to NCBI, no account and no request form: the whole study as GSE11324_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA106643. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 17013392) ↗

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