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Gene expressions of T cells in each developmental stages in healthy volunteers and patients with rheumatoid arthritis

GSE118829 Homo sapiens Expression profiling by high throughput sequencing 336 samples Submitted 2019/06/06 Platform GPL17303
Summary
We collected and compared samples from the cohort consisted of six groups as follows: methotrexate (MTX) monotherapy, combination therapy of MTX and infliximab (IFX), tocilizumab (TCZ) monotherapy, age- and gender-matched HC, and a small number of synovial fluid samples. In order to reduce variation due to the proportion of cells at each developmental stage, we performed transcriptome analysis after sorting CD4+ and CD8+ T cells according to developmental stage. We created a gene list that was significantly expressed in RA T cells, and revealed that pathways such as mTORC1, IL-2-stat5, Cell cycle and interferon-related genes were significantly enriched among them.
Published in
Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell
Takeshita M, Suzuki K, Kondo Y et al. · Annals of the rheumatic diseases 2019 · PMID 31167762 · doi:10.1136/annrheumdis-2018-214885
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Direct links to NCBI, no account and no request form: the whole study as GSE118829_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 336 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA486920 and SRA study SRP158491. Searching any of these in the dataset finder brings you back here.

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