GEO series

Role of BAP1 in pancreatic cancer (PrimeView)

GSE120078 Homo sapiens Expression profiling by array 8 samples Submitted 2020/04/14 Platform GPL15207

Summary

Transcriptional profile of PANC1 cells with CRISPR/Cas9 mediated deletion of BAP1 We found that BAP1 (BRCA1 Associated Protein-1) shows loss of heterozygosity in over 25% of pancreatic cancer patients and functions as tumor suppressor. Conditional deletion of Bap1 in murine pancreas led to genomic instability, accumulation of DNA damage, and an inflammatory response that evolved to pancreatitis with full penetrance. Concomitant expression of oncogenic KrasG12D led to malignant transformation and development of invasive and metastatic pancreatic cancer. At the molecular level, BAP1 maintains the integrity of the exocrine pancreas by regulating genome stability and its loss confers sensitivity to radio- and platinum-based therapies.

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Direct links to NCBI, no account and no request form: the whole study as GSE120078_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA491699. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 32541668) ↗

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