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The impact of microRNAs on protein output

GSE12075 Mus musculus (mouse) Expression microarray 24 samples Submitted 2008/07/30 Platform GPL4133Platform GPL1261Platform GPL9185
At a glance

Expression microarray · mouse · 24 samples

What it is
Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism
Mus musculus (mouse)
Samples
24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed expression table (series matrix) and the array files, from NCBI.
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
This dataset
Open GSE12075 in finder → Find more microarray datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE12075_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA113329 and SRA study SRP003878. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 18668037) ↗
Study design
8 conditions, mostly in triplicate
Neutrophils cultured from miR-223 null mouse … ×3 Neutrophils cultured from wild-type mouse bon… ×3 miR-223 null murine neutrophils ×3 wild-type murine neutrophils ×3 4 days cultures from wild-type mouse bone mar… ×2 4 days cultures from miR-223 null mouse bone … ×2 8 days cultures from wild-type mouse bone mar… ×2 8 days cultures from miR-223 null mouse bone … ×2 +4 more

Supports a between-group comparison across 20 samples.

How we read this: 8 replicated groups read from 24 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.