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DNA methylation profiling of human CD4+ T helper cells reveals the epigenetic control of SLAMF7 expression in IFN-γ producing cells

GSE122030 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/10/20 Platform GPL16791
Summary
Naive CD4+T cells are highly plastic cells that - upon activation - can differentiate into various T helper (Th) cell fates characterized by the expression of specific transcription factors and effector cytokines. Their expression can be stabilized by epigenetic mechanisms including DNA methylation. So far, our knowledge about the link between DNA methylation and T helper cell differentiation processes is fragmentary. After the identification of differentially methylated regions (DMRs) in human T helper cells we enlarged the characterization by analysing the transcriptome of ex vivo isolated and sorted naive T cells, Th1 and Th17 cells. This enables us to study the differential gene expression among CD4+T helper subsets, identify links between transcriptome and methylome, and search for expressed transcription factors that could bind to DMRs.
Published in
DNA methylation profiling of human CD4(+) T helper cells reveals the epigenetic control of SLAMF7 expression in IFN-γ producing cells
Ntalli A, Beckstette M, Kumar S et al. · Immunology and cell biology 2026 · PMID 41187703 · doi:10.1111/imcb.70063
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Also filed as BioProject PRJNA503190 and SRA study SRP167352. Searching any of these in the dataset finder brings you back here.

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