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Identification of differentially expressed genes by rapid induction of PML/RARa degradation using arsenic trioxide in NB4 cells

GSE126623 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/14 Platform GPL20795
Summary
Acute promyelocytic leukemia (APL) is characterized by the specific chromosome translocation t(15;17) that generates the promyelocytic leukemia/retinoic acid receptor-α (PML/RARα) fusion gene. Arsenic trioxide has been intensively reported to directly and rapidly degrade the PML/RARα fusion protein. Here, we treated NB4 cells (a widely used APL cell line) with arsenic trioxide and performed RNA-seq analysis to identify differentially expressed genes upon arsenic trioxide treatment.
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Also filed as BioProject PRJNA522748 and SRA study SRP186001. Searching any of these in the dataset finder brings you back here.

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