SenCat: Redefining human cell senescence through multiomic profiling of multiple senescent cell types

There is an urgent need to comprehensively catalog senescence markers across a wide range of cell types in an organism. Here, we profiled the transcriptomes and proteomes in over 30 senescence paradigms employing 14 different primary human cell types. Our results indicate that senescent cells from all tissue types do not share a unique marker, but they do share in the activation of specific metabolic pathways and damage response pathways to elicit tissue repair. Importantly, considering combinations of some of the most widely shared senescence markers validated the presence of senescent-like cells in mice through single-cell RNA-sequencing and immunostaining approaches. The enclosed catalog represents a much-needed resource to identify senescent cells across tissues in the body.