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Discovery of somatic mutations in lung adenocarcinomas

GSE12667 Homo sapiens Expression profiling by array 75 samples Submitted 2008/09/05 Platform GPL570
Summary
This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are likely to play a role in carcinogenesis. The observed mutational profiles correlate with clinical features, smoking status, and DNA repair defects. These results are complemented by data integration including SNP array data and gene expression array data (deposited here). Our findings shed further light on several key signaling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.
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Direct links to NCBI, no account and no request form: the whole study as GSE12667_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 75 samples.

Also filed as BioProject PRJNA112737. Searching any of these in the dataset finder brings you back here.

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