Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma

We have employed a single cell sequencing approach using 10x Genomics scRNAseq and scTCR-seq to study the heterogeneity and molecular architecture of tumor microenvironment (TME) caused by BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma (LUAD). LUADs are considered to be a heterogeneity population in the lung epithelium. Homologous recombination repair (HRR) deficiency has been linked to enhanced immunotherapy responses in non-small cell lung cancer patients. The HRR genes BRCA1 and BRCA2 are key regulators of DNA repair, yet their impact on the TME in LUAD remains unclear.This study provides a comprehensive characterization of the BRCA-mutant TME in LUAD patients, uncovering distinct immune response mechanisms and potential therapeutic strategies. These findings enhance our understanding of BRCA1/2-driven molecular architecture and offer novel insights into improving therapy efficacy in LUAD.