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Enforcement of stem-cell dormancy by NPMc+ is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

GSE133077 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/01 Platform GPL13112
Summary
Purpose: Analysis of downstream pathways activated by NPMc+ and Flt3-ITD oncogenes in preleukemic hematopoietic stem cells (HSCs). Methods: RNA extracted and processed from MxCRE, Flt3-ITD and NPMc+/Flt3-ITD FACS sorted HSCs Results: These data demonstrate that NPMc+ expression in Flt3-ITD HSCs promote a transcriptional program that supports both self-renewal and quiescence.
Published in
Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis
Merlo MEB, Mallardo M, Luzi L et al. · Haematologica 2025 · PMID 40079083 · doi:10.3324/haematol.2024.286577
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Also filed as BioProject PRJNA549886 and SRA study SRP201994. Searching any of these in the dataset finder brings you back here.

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