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Loss function of Fkbp5 leads to gene network alterations related to neuron development, mitochondria morphology, and calcium permissiveness at baseline and in alcohol stimulation conditions

GSE143354 Mus musculus (mouse) RNA-seq (gene expression) 32 samples Submitted 2026/01/02 Platform GPL13112
At a glance

RNA-seq (gene expression) · mouse · 32 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
32 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related PathwaysCells · 2023
Summary (written by the submitters)
RNA-seq was performed on the hippocampus of Fkbp5 KO and WT control mice with and without alcohol IP injection at 2g EtOH/Body weight dose
Published in
Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related Pathways
Williams KE, Zou Y, Qiu B et al. · Cells 2023 · PMID 38201293 · doi:10.3390/cells13010089
This dataset
Open GSE143354 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE143354_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA600234 and SRA study SRP240923. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 38201293) ↗
Study design
8 conditions, mostly with about 4 replicates each
hi_alc_f_ko ×4 hi_alc_f_wt ×4 hi_alc_m_ko ×4 hi_alc_m_wt ×4 hi_naive_f_KO ×4 hi_naive_f_wt ×4 hi_naive_m_KO ×4 hi_naive_m_wt ×4

Supports a between-group comparison across 32 samples.

How we read this: 8 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.