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Pharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits

GSE318028 Mus musculus (mouse) RNA-seq (gene expression) 246 samples Submitted 2026/07/15 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 246 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
246 samples: 36 conditions, mostly with about 7 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity-Induced Social Deficits in Male MiceAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Summary (written by the submitters)
Early life adversity (ELA) is a major risk factor for psychiatric disorders, but targeted preventative strategies are lacking due to poor mechanistic insight. The FKBP51 protein, a co-chaperone of the glucocorticoid receptor, is a key mediator of stress vulnerability. We tested if pharmacological inhibition of FKBP51 with the selective inhibitor SAFit2 prevents the long-term consequences of ELA.
Read the full summary ↓
Mice exposed to ELA exhibited persistent deficits in social behavior, manifesting as social subordination in adolescence and adulthood. Early-life SAFit2 treatment fully rescued these ELA-induced behavioral impairments. Transcriptional profiling across six stress-relevant brain regions revealed that SAFit2 normalized ELA-driven gene expression changes, particularly in the medial prefrontal cortex and nucleus accumbens. Functional analysis showed the rescue converged on immunoregulatory and neuroactive ligand-receptor signaling pathways. Our findings establish FKBP51 as a critical pharmacological target for reversing the lasting impact of early life adversity on brain function, offering a path toward preventative treatment for ELA-related psychopathology.
Published in
Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity-Induced Social Deficits in Male Mice
Bordes J, Ji X, Gasperoni S et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 42263247 · doi:10.1002/advs.76040
This dataset
Open GSE318028 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318028_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1416346 and SRA study SRP670474. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42263247) ↗
Study design
36 conditions, mostly with about 7 replicates each
PFC_ELA_Vehicle_NoInteraction ×7 PFC_ELA_Vehicle_SocialInteraction ×7 PFC_ELA_SAFit2_NoInteraction ×7 PFC_Ctrl_Vehicle_NoInteraction ×7 PFC_ELA_SAFit2_SocialInteraction ×7 ACC_ELA_Vehicle_NoInteraction ×7 ACC_ELA_Vehicle_SocialInteraction ×7 ACC_ELA_SAFit2_NoInteraction ×7 +28 more

Supports a between-group comparison across 246 samples.

How we read this: 36 replicated groups read from 246 sample titles; they account for 246 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 206 more — browse all 246 samples with per-sample file links →

Datasets on a similar topic

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