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Functionally distinct subset of monocytes in mouse and human blood [ATAC-Seq]

GSE148549 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 48 samples 2024/04/10 GPL17021GPL19057
Summary
Here, we used an inducible and reversible system to pause myeloid differentiation at a self-renewing state. These cells were clonally isolated and allowed to differentiate to test whether function was clone-specific and clonally restricted. We found that monocytic subsets exist with inherent, restricted capabilities which differ in their capacity to perform traditional monocytic functions.
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