Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically-unhealthy lean phenotype in female mice during aging
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Adipocyte-specific inactivation of NAMPT, a key NAD(+) biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during agingAmerican journal of physiology. Endocrinology and metabolism · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE152067_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA638180 and SRA study SRP266513. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 16 more — browse all 16 samples with per-sample file links →
- GSE306999 Vitamin B12 Ameliorates Diabetic complications: potential role of Circadian pathway and the NAMPT–NAD⁺–SIRT1 Pathway 16 samples shares nampt, nad
- GSE304351 NAD+ enhanced mesenchymal stromal cells effect on muscle atrophy by improving SIRT1/PGC-1α-mediated mitochondrial function via NAMPT 8 samples shares nampt, nad
- GSE271798 NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich’s Ataxia 50 samples shares nad, phenotype
- GSE313699 Loss of NADPH-producing enzymes accelerates pancreatic precancerous lesions 14 samples shares nad, enzyme
- GSE304104 Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue 141 samples shares nad
- GSE330309 Impact of Sex Chromosomes and Gonad Type in Stress Susceptibility in Corticostriatal Brain Regions 96 samples shares nad
- GSE291544 Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice [junctional zone/decidua] 60 samples shares nad
- GSE285453 Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice 60 samples shares nad
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.